Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC Pep2-8 TFA | 98.8% | 1715.85 (free base) | 1 MG
Pep2-8 is a peptide that enhances the antagonistic activity of proprotein convertase subtilin/kexin type 9 (PCSK9). It binds to C-terminally truncated PCSK9 and restored LDL uptake of PCSK9-treated HepG2 cells to approximately 90% of control activity at a concentration of 50 μM.
- Enhances antagonistic activity of proprotein convertase subtilin/kexin type 9 (PCSK9)
- Binds to C-terminally truncated PCSK9
- Restores LDL uptake of PCSK9-treated HepG2 cells to approximately 90% of control activity
- For research use only
Medchemexpress LLC Ribupatide (TFA) | 2940971-65-1 | >91.6% | 4907.523 | 25 MG
Ribupatide (TFA) is a dual gastric inhibitory polypeptide (GIP) and glucagon-like peptide 1 (GLP-1) receptor agonist, suitable for various laboratory research applications. This synthetic peptide is often studied in antidiabetic research and related metabolic disease areas.
- Dual GIP/GLP-1 receptor agonist
- Ideal for antidiabetic research
- High purity for reliable results
- Synthetic peptide for consistent quality
- Suitable for various laboratory applications
Medchemexpress LLC LIH383 | 2866266-58-0 | 99.8% | 997.22 | 1 MG
LIH383 is an agonist of ACKR3 (CXCR7) with an EC50 of 0.61 nM. It efficiently induces the recruitment of β-arrestin to ACKR3 but does not trigger typical G protein signaling.
- Agonist of ACKR3 (CXCR7)
- Efficiently induces recruitment of β-arrestin to ACKR3
- Does not trigger typical G protein signaling
Medchemexpress LLC SAIRGA (TFA) | 99.6% | 573.64 | 1 MG
SAIRGA (TFA) is a chemical derived from the phages phi3T, capable of recognizing phAimR in the bacterial cytosol to induce lysogeny. This product is suitable for use as a laboratory chemical in the manufacture of various substances.
- Solid appearance
- Has a purity of 99.6%
- Features a molecular weight of 573.64
- Stable under recommended storage conditions
- Suitable for research applications only
- Store at -80°C for up to 2 years or -20°C for up to 1 year (powder, sealed storage, away from moisture and light)
Medchemexpress LLC PSMA I&S TFA | 98.2% | 1413.43 | 1 MG
PSMA I&S (TFA) is a precursor of the 99mTc-labeled PSMA-targeting ligand, appearing as a white to off-white solid.
- Target PSMA
- Inhibits immunology/inflammation pathway
- Soluble in DMSO (100 mg/mL)
- Soluble in various in vivo dissolution methods
- Store at -20°C, protected from light and under nitrogen
Medchemexpress LLC Glycyl-exatecan TFA | 1883333-57-0 | 96.9% | 606.52 g/mol | C28H26F4N4O7 | 5 MG
Glycyl-exatecan TFA is a synthetic trifluoroacetate salt derivative of exatecan used as an experimental anticancer compound in research. It is supplied in solid and DMSO solution formats for in vitro and in vivo pharmacology studies; consult supplier documentation and the SDS for handling and storage guidelines.
- Trifluoroacetate salt form.
- Molecular formula C28H26F4N4O7.
- Molecular weight 606.52 g/mol.
- Purity typically around 96.9%.
- Available in small-scale sizes and 10 mM DMSO solutions.
- Intended for research use only in oncology and pharmacology.
- Handle according to SDS and laboratory safety procedures.
TARGETMOL CHEMICALS INC 6H05 TFA 5MG
Also available in 1mg 2mg 10mg 25mg 50mg 100mg and bulk. Please contact Fisher for quotes. 6H05 TFA (6H05 trifluoroacetate) is a selective and allosteric oncogenic mutant K-Ras(G12C) inhibitor. purity: 98%
Medchemexpress LLC XMD-17-51 TFA 10mM 1mL | 2436579-93-8 | 1 ML
XMD-17-51 (TFA) is a pyrimido-diazepinone small molecule that modulates protein kinases. It is supplied as the trifluoroacetate (TFA) salt and is provided as either a dry solid or a ready-to-use solution for biochemical and cell signaling research.
- Modulates protein kinases for biochemical and cellular studies
- Supplied as trifluoroacetate (TFA) salt, available as dry solid or solution
- Typical solution: 10 mM in DMSO, 1 mL
- High purity (LCMS 99.46%)
- White to off-white solid appearance
- Storage: 4°C for solid; in solvent -80°C (up to 6 months) or -20°C (up to 1 month)
Medchemexpress LLC REDV TFA | >99.81% | 517.53 | 25 MG
REDV TFA is the minimal active sequence within the CS5 site of the alternatively spliced type III connecting segment (IIICS) region of fibronectin. It mediates adhesion to the IIICS region of plasma fibronectin by binding the integrin alpha 4 beta 1 (α4β1). This peptide can be utilized in the research of cell adhesion.
- Target: Integrin
- Pathway: Cytoskeleton
- Storage (powder): -80°C for 2 years, -20°C for 1 year (sealed, away from moisture and light)
- Storage (in solvent): -80°C for 6 months, -20°C for 1 month (sealed, away from moisture and light)
- Solubility (in vitro): H₂O: 100 mg/mL (requires ultrasonic)
- Biological activity: Mediates adhesion to the IIICS region of plasma fibronectin by binding the integrin alpha 4 beta 1(a4β1)
Medchemexpress LLC MPSD TFA (MARCKS-ED TFA) | 99.8% | 3080.76 | 5 MG
MPSD TFA is the TFA salt form of MPSD, a 25-amino acid peptide derived from the effector domain sequence of the intracellular membrane protein myristoylated alanine-rich C-kinase substrate (MARCKS). It functions as a biological probe to study membrane curvature and lipid composition, specifically recognizing phosphatidylserine.
- TFA salt form of MPSD
- 25-amino acid peptide
- Derived from MARCKS protein
- Detects membrane curvature
- Identifies phosphatidylserine
- Useful as a biological probe
- White to off-white solid appearance
- Soluble in DMSO and H2O
Medchemexpress LLC BIM 23042 trifluoroacetate | 00-00-0 | 96.2% | 1192.45 g/mol (free base) | C63H73N11O9S2.xC2HF3O2 | 5 MG
BIM 23042 TFA is a somatostatin-like octapeptide analogue that functions as a selective antagonist of the neuromedin B receptor (NMB-R/BB1). Supplied as the trifluoroacetate (TFA) salt at high purity, it is intended for research use in receptor pharmacology and related biochemical assays.
- Selective antagonist of neuromedin B receptor (BB1).
- TFA salt form for improved handling and stability.
- High purity suitable for receptor pharmacology and calcium mobilization assays.
- Supplied as a small, lyophilized quantity for laboratory research use.
- Molecular weight and elemental composition available in the product documentation.
Medchemexpress LLC MPSD control peptide (TFA) | 99.8% | 3080.76 (free base) | 1 MG
MPSD TFA (MARCKS-ED TFA) is the TFA salt form of MPSD, a 25-amino acid peptide derived from the myristoylated alanine-rich C-kinase substrate (MARCKS). It functions as a biological probe capable of sensing membrane curvature and recognizing phosphatidylserine, making it useful for studying membrane shape and lipid composition.
- Derived from MARCKS effector domain sequence
- Senses membrane curvature
- Recognizes phosphatidylserine
- Useful for studying membrane shape and lipid composition
- Appears as a white to off-white solid
- High purity (99.8%)
- Molecular weight: 3080.76 (free base)
Medchemexpress LLC CGGRGD TFA | 98.7% | 677.61 | 5 MG
CGGRGD TFA is a derivative of RGD (Arginine-Glycine-Aspartic acid) that includes cysteine at its N-terminal. This product is intended for research applications only and not for human use. It is referenced in publications regarding the functionalization of PCL fibrous membranes with RGD peptide.
- Biological activity: a derivative of RGD with cysteine at its N-terminal
- Purity: 98.66%
- Molecular weight: 677.61
- Formula: C21H34F3N9O11S
- Appearance: solid
- Color: white to off-white
- Sequence: Cys-Gly-Gly-Arg-Gly-Asp
- Sequence shortening: CGGRGD
- Solubility in vitro: soluble in DMSO at 100 mg/mL (147.58 mM); ultrasonic assistance may be needed, and newly opened DMSO is recommended due to hygroscopic impact on solubility
Medchemexpress LLC Maculatin 1.1 TFA | 96.9% | 2145.55 | 500 UG
Maculatin 1.1 TFA is an antimicrobial peptide that exhibits a Minimum Inhibitory Concentration (MIC) of 7 μM against *Staphylococcus aureus*. This peptide functions by perforating the bacterial membrane of *Staphylococcus aureus*, ultimately leading to bacterial death.
- Antimicrobial peptide.
- Effective against *Staphylococcus aureus* with an MIC of 7 μM.
- Works by perforating the bacterial membrane.
Medchemexpress LLC TD-0212 TFA 10mM | 10MM 1ML
TD-0212 TFA is an orally active dual pharmacology angiotensin II type 1 receptor (AT1) antagonist and neprilysin (NEP) inhibitor with a pKi of 8 9 for AT1 and a pIC50 of 9 2 for NEP[1]