Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC Alvespimycin (17-DMAG) trifluoroacetate | 00-00-0 | MFCD08457919 | 99.0% | 730.77 g/mol | C34H49F3N4O10 | 5 MG
Alvespimycin TFA is the trifluoroacetate salt of 17-DMAG, a small-molecule inhibitor of heat shock protein 90 (Hsp90) used as a research reagent to study Hsp90-dependent signaling and anticancer mechanisms. The compound binds Hsp90 with an EC50 of 62 nM and is supplied as a high-purity, pale purple solid for laboratory use.
- Potent Hsp90 inhibitor (EC50 62 nM).
- Trifluoroacetate (TFA) salt form for consistent handling.
- High purity (reported ~98.97%).
- Molecular weight 730.77 g/mol.
- Pale purple solid appearance.
- Storage: sealed, away from moisture and light; in solvent, -80°C (6 months) or -20°C (1 month).
Medchemexpress LLC Ac-VEID-CHO (trifluoroacetate salt) | 00-00-0 | 99.8% | 614.57 Da | C24H37F3N4O11 | 1 MG
Ac-VEID-CHO (TFA) is a peptide-derived reversible caspase inhibitor intended for in vitro research into apoptosis and neurodegenerative pathways. It is supplied as a trifluoroacetate salt and demonstrates potent inhibition of several executioner caspases in biochemical assays. Not for human or clinical use.
- Reversible caspase inhibitor targeting caspase-6, caspase-3, and caspase-7.
- Reported IC50 values in the low nanomolar range for primary targets.
- High purity suitable for biochemical assays (99.8%).
- Available in small mg-scale quantities for research use.
- Limited cellular activity due to poor cellular accumulation.
Sigma Aldrich Fine Chemicals Biosciences TRIFLUOROACETIC ACID 100ML
NC3241523 TRIFLUOROACETIC ACID 100ML
Medchemexpress LLC Zifanocycline trifluoroacetate | 00-00-0 | 99.8% | 666.64 g/mol | C31H37F3N4O9 | 5 MG
Zifanocycline TFA is an orally active, semi-synthetic aminomethylcycline antibiotic supplied as the trifluoroacetate salt for research use. It inhibits bacterial ribosome function and demonstrates broad-spectrum in vitro activity against Gram-positive and Gram-negative bacteria, including multidrug-resistant strains. Supplied at high purity for laboratory studies and antimicrobial research applications.
- Orally active aminomethylcycline antibiotic.
- Broad-spectrum activity against gram-positive and gram-negative bacteria.
- Useful for studying skin infections, community-acquired pneumonia, and intra-abdominal infections.
- High purity, suitable for analytical and biological assays.
- Provided as the trifluoroacetate (TFA) salt for improved handling.
- Molecular weight 666.64 g/mol.